How Gut Permeability Changes with Aging & How to Prevent It As people age, gut permeability often increases, leading to a condition known as leaky gut." This happens because the intestinal lining becomes weaker, allowing harmful substances like bacteria, toxins, and undigested food particles to pass into the bloodstream. Why Does Gut Permeability Increase with Age? 1. Weakened Intestinal Barrier – The cells in the gut lining regenerate more slowly, making the barrier weaker. 2. Changes in Gut Microbiome – Aging alters the balance of good and bad bacteria, affecting gut health. 3. Chronic Inflammation – Low-grade inflammation (common in older adults) weakens the gut lining. 4. Reduced Digestive Enzymes & Stomach Acid – This makes it harder to break down food, increasing irritation. 5. Lifestyle Factors- Poor diet, stress, medication (like NSAIDs and antibiotics), and alcohol can further damage the gut lining. ...